Macs is an ongoing prospective study of the natural and treated histories of HIV-1 infection in homosexual and bisexual men conducted by sites located in:
Baltimore, Chicago, Pittsburgh and Los Angeles.


History of the MACs

In the fall of 1983, a group of investigators met at the National Institutes of Health (NIH ) to design a prospective epidemiologic study of the newly recognized immunodeficiency syndrome in men who had sex with men (MSM) in Los Angeles, San Francisco, and New York. Upon completion of designing the protocol, recruitment of MSM began in April of 1984 into the investigation which was named The Multicenter AIDS Cohort Study or MACS. The first wave of participant recruitment was completed by March 31, 1985. Since then three more periods of enrollment have been opened; the first in 1987 to increase the participation of African-American (AA) MSM in the study and the second in 2001 to again increase participation by AA and Hispanic MSM. In 2011, the last enrollment period was initiated focusing on men . As of October 2013, 7087 men have volunteered and participated in the MACS. The currently active participants number 2340; 35 % are non white and half of all participants are older than 55 years of age. In Chicago 1387 men have enrolled into the study.

The initial recruitment in 1984-85 was carried out before we had a laboratory test to determine who was a risk of developing AIDS. HIV had been suggested as the cause of the immunodeficiency in 1983 by investigators at the Pasteur Institute in Paris but this was not confirmed until the spring of 1984ot by investigators in San Francisco and the NIH in the spring of 1984. However, a blood test to determine who was infected did not become available until the spring of 1985. When the original group of MSM who had joined the MACS underwent testing it was discovered that approximately 40 percent of the cohort was infected.

This allowed the MACS to address two important issues. First, we could determine the behaviors, clinical findings and laboratory results which were associated with progression from HIV infection to AIDS. Secondly among the uninfected men, the behaviors that led to HIV infection and the early signs and symptoms of this viral infection could be elucidated. To date 712 uninfected men at entry into the MACS acquired HIV infection during the study, 333 developed AIDS and 82.9% of these men have died.

Early in the course of the study it became apparent that dementia was a major problem for men who developed advanced HIV infection and AIDS. MACS investigators organized a working group of neurologists to investigate this problem. The most important early finding was that severe central nervous system (brain and spinal cord) problems were seen only in persons with AIDS and that there was no reason for HIV infected men without AIDS to be restricted in their work. This finding became the basis of World Health Organization recommendation which was widely accepted advising that persons with HIV infection need not be restricted in their activities.

During the period of the 1980s the death rate among the infected MACS participants was very high. As of the fall of 2013, close to 90 percent of men who entered the MACS with HIV infection have died. The MACS investigators were among the first to demonstrated that the T-Helper cell count below 200/mm3 were associated with a high rate of pneumocystis pneumonia (PCP) and helper cell counts below 100/mm3 put individuals at risk for cytomegalovirus retinitis, atypical mycobacterial infections, and infection of the brain with the parasite Toxoplasma gondii. Giving antibiotics to prevent some of these opportunistic infections helped but the early agents available to treat the HIV infection did not prevent progression to AIDS or death.

An early observation of MACS investigators was that the progression of newly acquired HIV infections to AIDS differed from individual to individual. Determinants of this heterogeneity included age at the time of infection and host genetics. The genetic makeup of an individual determines their immune response to HIV which in turn controls the rate of viral replication. Lower levels of replication result in slower progression of untreated HIV infection. Host genetics also determines susceptibility to HIV infection. The MACS contributed to the discovery of an uncommon mutation which protects people with this mutation from the usual form of HIV which is transmitted sexually.

With the availability of effective antiretroviral therapy in late 1995 progression to AIDS and death decreased dramatically in men on therapy. Close to 80% of participants in the MACS taking drugs have suppressed HIV replication and the median T-helper cell count is near 600/mm3. Stopping drug treatment results in progression of HIV infection and disease. With this greatly improved survival of infected participants the MACS has focused upon the health status of men who were living longer. To accomplish this investigators have been recruited into working groups with interest in diseases of the heart, lungs, kidneys, liver and metabolic diseases such as diabetes. The behavioral working group has continued to study behaviors to determine why men fail to adhere to treatment. Recreational drugs and alcohol use have been shown to be associated with poor adherence. Drug use also is associated with a marked increase in the risk of acquiring HIV infection. The neurology working group continues to investigate brain function among aging HIV infected men and the Aging working group is attempting to determine whether or not HIV infected men age more rapidly than in infected men.

The long follow up and presence of both HIV infected and uninfected men provide the MACS with a unique insight into men's health.

Update on MACS Substudies

BOSS: As MACS participants grow older, it has become important to understand the effects of HIV on the aging process. The purpose of the MACS Bone Strength Study is to understand whether older HIV-positive men have a higher risk of fracture compared to HIV-negative men of a similar age. For this, approximately 400 men from the MACS study have undergone a series of tests including DXA and CAT scans, a blood draw, and some simple clinical tests. In fact, many people in the MACS study have participated in these simple clinical tests, as the balancing assessments were recently added to the standard set of tests given to all MACS participants, and anyone between the ages of 60 and 69 has been asked to participate by doing reaching assessments and chair stands. Based on the self-reported data from those participating in the MACS and those participating in the BOSS, preliminary results show that poor balance confidence doubled the odds of falling, where balance and physical function tests did not predict falls. And while there was no significant difference in the proportion of men with HIV who fell versus those without, the HIV group had significantly higher rate of falls with fracture. To see more about preliminary findings, see the link below.

Boss study: http://www.natap.org/2015/CROI/croi_02.htm

CDV: The MACS has done multiple Cardiovascular sub-studies and has just recently begun it’s third. The cardiovascular studies have been conducted to explore the relationship between HIV infection and the narrowing, blockage or hardening of the heart, also known as atherosclerosis. The second cardiovascular study run in 2009/2010, included 764 participants of the MACS, aged 40-70 years. Findings showed that a greater prevalence and extent of non-calcified plaque – more prone to rupture, therefore precipitating thrombosis and acute coronary syndromes than calcified plaque – among HIV positive men than HIV negative men. These findings suggest that men with HIV infection are at an increased risk for the development of coronary artery disease. Now, the third MACS cardiovascular sub-study has commenced with the objective of determining whether atherosclerosis increases faster in HIV positive men than in HIV negative men. 172 men of the MACS study who have participated in the two prior subclinical cardiovascular protocols are getting a series of CAT scans, some after having an injection of contrast dye, to take pictures of the blood vessels and body fat, as well as a blood test. To find out more about the results of the last cardiovascular study, check out the link below.

Cardiovascular Study: http://www.nih.gov/news/health/mar2014/niaid-31.htmI

POPS: Many men of the MACS study have participated in the POPS sub-study, and although many participants have anticipated the mouthwash rinse with lackluster enthusiasm, the study has been doing very important work in regards to oral HPV. Due to the assistance of the MACS participants who helped with this study, the POPS was able to observe an increased risk for oral HPV for those with a reduced current CD4 cell count, and no history of a tonsillectomy. The study also observes an increased risk of oral HPV with greater numbers of recent partners for oral sex and rimming for HIV uninfected, and increased risk with greater number of lifetime partners for HIV infected. Factors such as gender, smoking habits, and age significantly decreased the clearance of infection. To find out more about the POPS and its initial findings, see the POPS newsletter link below.

What To Do

This site is designed to assist in enrollment and the management of enrolled accounts as well as offer general information about MACs.


Haven't enrolled yet? Start here.Enrollment is the first step of your participation in the MACs study.

Sign In

Already enrolled? Sign in here. Update your personal and contact information if you are already enrolled.

Eligibility Criteria

In order to be eligible to NEWLY enroll in the MACs, you must meet the following criteria:


Aged 18-70

Evidence of recent HIV infection

evidence of HIV infection may include:
+ Ag/Ab test
+ HIV viral load
Indeterminate or negative Western blot

As an observational study no medications are provided, you will receive laboratory and other medical evaluations as part of the study and will be compensated for your time.


POPS newsletter

Other Links

Publications for 2009

  1. An P, Johnson R, Phair J, Kirk GD, Yu XF, Donfield S, Buchbinder S, Goedert JJ, Winkler CA. APOBEC3B deletion and risk of HIV-1 acquisition. J Infect Dis. 2009; 200(7): 1054-8. PMCID: PMC3690486
  2. Becker JT, Kingsley L, Mullen J, Cohen B, Martin E, Miller EN, Ragin A, Sacktor N, Selnes OA, Visscher BR. Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men. Neurology. 2009; 73(16): 1292-9. PMCID: PMC2764414
  3. Bhattacharya T, Stanton J, Kim EY, Kunstman KJ, Phair JP, Jacobson LP, Wolinsky SM. CCL3L1 and HIV/AIDS susceptibility. Nat Med. 2009; 15(10): 1112-5. PMC exempt.
  4. Brown TT, Xu X, John M, Singh J, Kingsley LA, Palella FJ, Witt MD, Margolick JB, Dobs AS. Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: a substudy of the Multicenter AIDS Cohort Study. AIDS Res Ther. 2009; 6: 8. PMCID: PMC2686733
  5. Cain LE, Cole SR, Greenland S, Brown TT, Chmiel JS, Kingsley L, Detels R. Effect of highly active antiretroviral therapy on incident AIDS using calendar period as an instrumental variable. Am J Epidemiol. 2009; 169(9): 1124-32. PMCID: PMC2732979
  6. Chao C, Jacobson LP, Jenkins FJ, Tashkin D, Martinez-Maza O, Roth MD, Ng L, Margolick JB, Chmiel JS, Zhang ZF, Detels R. Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men. AIDS Res Hum Retroviruses. 2009; 25(2): 149-56. PMCID: PMC2981355
  7. Chao C, Jacobson LP, Tashkin D, Martinez-Maza O, Roth MD, Margolick JB, Chmiel JS, Holloway MN, Zhang ZF, Detels R. Recreational amphetamine use and risk of HIV-related non-Hodgkin lymphoma. Cancer Causes Control. 2009; 20(5): 509-16. PMCID: PMC2862618
  8. Desquilbet L, Margolick JB, Fried LP, Phair JP, Jamieson BD, Holloway M, Jacobson LP. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009; 50(3): 299-306. PMCID: PMC2699396
  9. Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Gunthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB. Common genetic variation and the control of HIV-1 in humans. PLoS Genet. 2009; 5(12): e1000791. PMCID: PMC2791220
  10. Hendrickson SL, Kingsley LA, Ruiz-Pesini E, Poole JC, Jacobson LP, Palella FJ, Bream JH, Wallace DC, O'Brien SJ. Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009; 51(2): 111-6. PMCID: PMC2742970
  11. Herbeck JT, Gottlieb GS, Wong K, Detels R, Phair JP, Rinaldo CR, Jacobson LP, Margolick JB, Mullins JI. Fidelity of SNP array genotyping using Epstein Barr virus-transformed B-lymphocyte cell lines: implications for genome-wide association studies. PLoS One. 2009; 4(9): e6915. PMCID: PMC2731852
  12. Hoffmann CJ, Seaberg EC, Young S, Witt MD, D'Acunto K, Phair J, Thio CL. Hepatitis B and long-term HIV outcomes in coinfected HAART recipients. AIDS. 2009; 23(14): 1881-9. PMCID: PMC2861825
  13. Horne KC, Li X, Jacobson LP, Palella F, Jamieson BD, Margolick JB, Martinson J, Turkozu V, Visvanathan K, Woolley IJ. Duffy antigen polymorphisms do not alter progression of HIV in African Americans in the MACS cohort. Cell Host Microbe. 2009; 5(5): 415-7; author reply 8-9. PMC exempt.
  14. Koning FA, Newman EN, Kim EY, Kunstman KJ, Wolinsky SM, Malim MH. Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets. J Virol. 2009; 83(18): 9474-85. PMCID: PMC2738220
  15. Oh DL, Sarafian F, Silvestre A, Brown T, Jacobson L, Badri S, Detels R. Evaluation of adherence and factors affecting adherence to combination antiretroviral therapy among White, Hispanic, and Black men in the MACS Cohort. J Acquir Immune Defic Syndr. 2009; 52(2): 290-3. PMCID: PMC2815178
  16. Oleksyk TK, Shrestha S, Truelove AL, Goedert JJ, Donfield SM, Phair J, Mehta S, O'Brien SJ, Smith MW. Extended IL10 haplotypes and their association with HIV progression to AIDS. Genes Immun. 2009; 10(4): 309-22. PMCID: PMC3664918
  17. Ostrow DG, Plankey MW, Cox C, Li X, Shoptaw S, Jacobson LP, Stall RC. Specific sex drug combinations contribute to the majority of recent HIV seroconversions among MSM in the MACS. J Acquir Immune Defic Syndr. 2009; 51(3): 349-55. PMCID: PMC3074969
  18. Sezgin E, Lind JM, Shrestha S, Hendrickson S, Goedert JJ, Donfield S, Kirk GD, Phair JP, Troyer JL, O'Brien SJ, Smith MW. Association of Y chromosome haplogroup I with HIV progression, and HAART outcome. Hum Genet. 2009; 125(3): 281-94. PMCID: PMC2885350
  19. Subramaniam K, Metzger B, Hanau LH, Guh A, Rucker L, Badri S, Pirofski LA. IgM(+) memory B cell expression predicts HIV-associated cryptococcosis status. J Infect Dis. 2009; 200(2): 244-51. PMCID: PMC2805277
  20. Taiwo BO, Li X, Palella F, Jacobson LP, Margolick JB, Detels R, Rinaldo CR, Phair JP. Higher risk of AIDS or death in patients with lower CD4 cell counts after virally suppressive HAART. HIV Med. 2009; 10(10): 657-60. PMCID: PMC2783359
  21. Trachtenberg E, Bhattacharya T, Ladner M, Phair J, Erlich H, Wolinsky S. The HLA-B/-C haplotype block contains major determinants for host control of HIV. Genes Immun. 2009; 10(8): 673-7. PMCID: PMC2873233
  22. Walzer PD, Djawe K, Levin L, Daly KR, Koch J, Kingsley L, Witt M, Golub ET, Bream JH, Taiwo B, Morris A. Long-term serologic responses to the Pneumocystis jirovecii major surface glycoprotein in HIV-positive individuals with and without P. jirovecii infection. J Infect Dis. 2009; 199(9): 1335-44. PMCID: PMC2714884

Publications for 2010

  1. Bachmann LH, Johnson RE, Cheng H, Markowitz L, Papp JR, Palella FJ, Jr., Hook EW, 3rd. Nucleic acid amplification tests for diagnosis of Neisseria gonorrhoeae and Chlamydia trachomatis rectal infections. J Clin Microbiol. 2010; 48(5): 1827-32. PMCID: PMC2863861
  2. Chinn LW, Tang M, Kessing BD, Lautenberger JA, Troyer JL, Malasky MJ, McIntosh C, Kirk GD, Wolinsky SM, Buchbinder SP, Gomperts ED, Goedert JJ, O'Brien SJ. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. J Infect Dis. 2010; 202(12): 1836-45. PMCID: PMC3107555
  3. Chu H, Gange SJ, Li X, Hoover DR, Liu C, Chmiel JS, Jacobson LP. The effect of HAART on HIV RNA trajectory among treatment-naive men and women: a segmental Bernoulli/lognormal random effects model with left censoring. Epidemiology. 2010; 21 Suppl 4: S25-34. NIHMSID: NIHMS325438
  4. Cole SR, Jacobson LP, Tien PC, Kingsley L, Chmiel JS, Anastos K. Using marginal structural measurement-error models to estimate the long-term effect of antiretroviral therapy on incident AIDS or death. Am J Epidemiol. 2010; 171(1): 113-22. PMCID: PMC2800300
  5. Cromer D, Wolinsky SM, McLean AR. How fast could HIV change gene frequencies in the human population? Proc Biol Sci. 2010; 277(1690): 1981-9. PMCID: PMC2880090
  6. Gao X, O'Brien TR, Welzel TM, Marti D, Qi Y, Goedert JJ, Phair J, Pfeiffer R, Carrington M. HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection. AIDS. 2010; 24(12): 1835-40. PMCID: PMC2902625
  7. Herbeck JT, Gottlieb GS, Winkler CA, Nelson GW, An P, Maust BS, Wong KG, Troyer JL, Goedert JJ, Kessing BD, Detels R, Wolinsky SM, Martinson J, Buchbinder S, Kirk GD, Jacobson LP, Margolick JB, Kaslow RA, O'Brien SJ, Mullins JI. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis. 2010; 201(4): 618-26. PMCID: PMC2928718
  8. Huhn GD, Badri S, Vibhakar S, Tverdek F, Crank C, Lubelchek R, Max B, Simon D, Sha B, Adeyemi O, Herrera P, Tenorio A, Kessler H, Barker D. Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution. AIDS Res Ther. 2010; 7: 44. PMCID: PMC3022662
  9. Hultin LE, Chow M, Jamieson BD, O'Gorman MR, Menendez FA, Borowski L, Denny TN, Margolick JB. Comparison of interlaboratory variation in absolute T-cell counts by single-platform and optimized dual-platform methods. Cytometry B Clin Cytom. 2010; 78(3): 194-200. PMCID: PMC3086643
  10. Kim EY, Bhattacharya T, Kunstman K, Swantek P, Koning FA, Malim MH, Wolinsky SM. Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure. J Virol. 2010; 84(19): 10402-5. PMCID: PMC2937764
  11. Kunstman KJ, Bhattacharya T, Flaherty J, Phair JP, Wolinsky SM. Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV. AIDS. 2010; 24(11): 1784-5. PMC exempt.
  12. Limou S, Coulonges C, Herbeck JT, van Manen D, An P, Le Clerc S, Delaneau O, Diop G, Taing L, Montes M, van't Wout AB, Gottlieb GS, Therwath A, Rouzioux C, Delfraissy JF, Lelievre JD, Levy Y, Hercberg S, Dina C, Phair J, Donfield S, Goedert JJ, Buchbinder S, Estaquier J, Schachter F, Gut I, Froguel P, Mullins JI, Schuitemaker H, Winkler C, Zagury JF. Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. J Infect Dis. 2010; 202(6): 908-15. PMCID: PMC3601691
  13. Lyons T, Chandra G, Goldstein J, Ostrow DG. Breaking the bond between stimulant use and risky sex: a qualitative study. Subst Abus. 2010; 31(4): 224-30. PMCID: PMC2978069
  14. Margolick JB, Da Costa Castro JM, Sanchez A, Gemrot F, Phair JP, Jamieson BD, Rinaldo CR, Jacobson LP. The relationship between antibody to R7V and progression of HIV type 1 infection. AIDS Res Hum Retroviruses. 2010; 26(4): 389-94. PMCID: PMC2933163
  15. Palella FJ, Jr., Gange SJ, Benning L, Jacobson L, Kaplan RC, Landay AL, Tracy RP, Elion R. Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study. AIDS. 2010; 24(11): 1657-65. PMCID: PMC3514460
  16. Sacktor N, Skolasky RL, Cox C, Selnes O, Becker JT, Cohen B, Martin E, Miller EN. Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus. J Neurovirol. 2010; 16(5): 335-41. PMCID: PMC3068912
  17. Sander PM, Cole SR, Ostrow DG, Mehta SH, Kirk GD. Determinants of alcohol consumption in HIV-uninfected injection drug users. Drug Alcohol Depend. 2010; 111(1-2): 173-6. PMCID: PMC2930039
  18. Seaberg EC, Benning L, Sharrett AR, Lazar JM, Hodis HN, Mack WJ, Siedner MJ, Phair JP, Kingsley LA, Kaplan RC. Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Stroke. 2010; 41(10): 2163-70. PMCID: PMC2972735
  19. Seaberg EC, Wiley D, Martinez-Maza O, Chmiel JS, Kingsley L, Tang Y, Margolick JB, Jacobson LP. Cancer incidence in the multicenter AIDS Cohort Study before and during the HAART era: 1984 to 2007. Cancer. 2010; 116(23): 5507-16. PMCID: PMC2991510
  20. Sezgin E, Drosdak A, McIntosh C, Kessing B, Lautenberger JA, Goedert JJ, Phair JP, Troyer JL, Smith MW, O'Brien SJ. Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I. J Hum Genet. 2010; 55(9): 613-20. PMCID: PMC2945452
  21. Shiels MS, Cole SR, Chmiel JS, Margolick J, Martinson J, Zhang ZF, Jacobson LP. A comparison of ad hoc methods to account for non-cancer AIDS and deaths as competing risks when estimating the effect of HAART on incident cancer AIDS among HIV-infected men. J Clin Epidemiol. 2010; 63(4): 459-67. PMCID: PMC2837111
  22. Westreich D, Cole SR, Tien PC, Chmiel JS, Kingsley L, Funk MJ, Anastos K, Jacobson LP. Time scale and adjusted survival curves for marginal structural cox models. Am J Epidemiol. 2010; 171(6): 691-700. PMCID: PMC2877453

Publications for 2011

  1. An P, Li R, Wang JM, Yoshimura T, Takahashi M, Samudralal R, O'Brien SJ, Phair J, Goedert JJ, Kirk GD, Troyer JL, Sezgin E, Buchbinder SP, Donfield S, Nelson GW, Winkler CA. Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. PLoS Genet. 2011; 7(10): e1002328. PMCID: PMC3203199
  2. Becker JT, Sanders J, Madsen SK, Ragin A, Kingsley L, Maruca V, Cohen B, Goodkin K, Martin E, Miller EN, Sacktor N, Alger JR, Barker PB, Saharan P, Carmichael OT, Thompson PM. Subcortical brain atrophy persists even in HAART-regulated HIV disease. Brain Imaging Behav. 2011; 5(2): 77-85. PMCID: PMC3082694
  3. Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, Margolick JB. A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men. J Gerontol A Biol Sci Med Sci. 2011; 66(9): 1030-8. PMCID: PMC3156632
  4. Estrella MM, Parekh RS, Astor BC, Bolan R, Evans RW, Palella FJ, Jr., Jacobson LP. Chronic kidney disease and estimates of kidney function in HIV infection: a cross-sectional study in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr. 2011; 57(5): 380-6. PMCID: PMC3159728
  5. Farrow MA, Kim EY, Wolinsky SM, Sheehy AM. NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G. J Biol Chem. 2011; 286(4): 2567-77. PMCID: PMC3024752
  6. Gingo MR, Lucht L, Daly KR, Djawe K, Palella FJ, Abraham AG, Bream JH, Witt MD, Kingsley LA, Norris KA, Walzer PD, Morris A. Serologic responses to pneumocystis proteins in HIV patients with and without Pneumocystis jirovecii pneumonia. J Acquir Immune Defic Syndr. 2011; 57(3): 190-6. PMCID: PMC3150634
  7. Greene JM, Wiseman RW, Lank SM, Bimber BN, Karl JA, Burwitz BJ, Lhost JJ, Hawkins OE, Kunstman KJ, Broman KW, Wolinsky SM, Hildebrand WH, O'Connor DH. Differential MHC class I expression in distinct leukocyte subsets. BMC Immunol. 2011; 12: 39. PMCID: PMC3155488
  8. Howe CJ, Cole SR, Chmiel JS, Munoz A. Limitation of inversRole.create(:id => 1, :name => "admin", :description => "Full access user.")e probability-of-censoring weights in estimating survival in the presence of strong selection bias. Am J Epidemiol. 2011; 173(5): 569-77. PMCID: PMC3105434
  9. Howe CJ, Cole SR, Ostrow DG, Mehta SH, Kirk GD. A prospective study of alcohol consumption and HIV acquisition among injection drug users. AIDS. 2011; 25(2): 221-8. PMCID: PMC3006640
  10. Julg B, Moodley ES, Qi Y, Ramduth D, Reddy S, Mncube Z, Gao X, Goulder PJ, Detels R, Ndung'u T, Walker BD, Carrington M. Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. J Infect Dis. 2011; 203(6): 803-9. PMCID: PMC3071131
  11. Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M. Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature. 2011; 472(7344): 495-8. PMCID: PMC3084326
  12. Li X, Margolick JB, Jamieson BD, Rinaldo CR, Phair JP, Jacobson LP. CD4+ T-cell counts and plasma HIV-1 RNA levels beyond 5 years of highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2011; 57(5): 421-8. PMCID: PMC3293185
  13. Longenberger A, Lim JY, Brown TT, Abraham A, Palella FJ, Effros RB, Orchard T, Brooks MM, Kingsley LA. Low physical function as a risk factor for incident diabetes mellitus and insulin resistance. Future Virol. 2011; 6(4): 439-49. PMCID: PMC3690565
  14. Martin E, Gonzalez R, Vassileva J, Maki P. HIV+ men and women show different performance patterns on procedural learning tasks. J Clin Exp Neuropsychol. 2011; 33(1): 112-20. PMCID: PMC2990780
  15. Monroe AK, Dobs AS, Xu X, Palella FJ, Kingsley LA, Witt MD, Brown TT. Sex hormones, insulin resistance, and diabetes mellitus among men with or at risk for HIV infection. J Acquir Immune Defic Syndr. 2011; 58(2): 173-80. PMCID: PMC3175332
  16. Ng DK, Schwartz GJ, Jacobson LP, Palella FJ, Margolick JB, Warady BA, Furth SL, Munoz A. Universal GFR determination based on two time points during plasma iohexol disappearance. Kidney Int. 2011; 80(4): 423-30. PMCID: PMC3146568
  17. Palella FJ, Jr., Phair JP. Cardiovascular disease in HIV infection. Curr Opin HIV AIDS. 2011; 6(4): 266-71. PMCID: PMC3501268
  18. Pelak K, Need AC, Fellay J, Shianna KV, Feng S, Urban TJ, Ge D, De Luca A, Martinez-Picado J, Wolinsky SM, Martinson JJ, Jamieson BD, Bream JH, Martin MP, Borrow P, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Carrington M, Goldstein DB, Alter G. Copy number variation of KIR genes influences HIV-1 control. PLoS Biol. 2011; 9(11): e1001208. PMCID: PMC3226550
  19. Phair J, Palella F. Renal disease in HIV-infected individuals. Curr Opin HIV AIDS. 2011; 6(4): 285-9. PMCID: PMC3266688
  20. Ragin AB, D'Souza G, Reynolds S, Miller E, Sacktor N, Selnes OA, Martin E, Visscher BR, Becker JT. Platelet decline as a predictor of brain injury in HIV infection. J Neurovirol. 2011; 17(5): 487-95. PMCID: PMC3472427
  21. Regidor DL, Detels R, Breen EC, Widney DP, Jacobson LP, Palella F, Rinaldo CR, Bream JH, Martinez-Maza O. Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation. AIDS. 2011; 25(3): 303-14. PMCID: PMC3322644
  22. Rickabaugh TM, Kilpatrick RD, Hultin LE, Hultin PM, Hausner MA, Sugar CA, Althoff KN, Margolick JB, Rinaldo CR, Detels R, Phair J, Effros RB, Jamieson BD. The dual impact of HIV-1 infection and aging on naive CD4 T-cells: additive and distinct patterns of impairment. PLoS One. 2011; 6(1): e16459. PMCID: PMC3027697
  23. Spindler J, Hackett J, Jr., Qiu X, Wiegand A, Boltz VF, Swanson P, Bream JH, Jacobson LP, Li X, Rinaldo CR, Wolinsky SM, Coffin JM, Kearney MF, Mellors JW. Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection. Adv Virol. 2011; 2011: 268214. PMCID: PMC3265298
  24. Tsao JC, Stein JA, Ostrow D, Stall RD, Plankey MW. The mediating role of pain in substance use and depressive symptoms among Multicenter AIDS Cohort Study (MACS) participants. Pain. 2011; 152(12): 2757-64. PMCID: PMC3215839
  25. Vassileva J, Georgiev S, Martin E, Gonzalez R, Segala L. Psychopathic heroin addicts are not uniformly impaired across neurocognitive domains of impulsivity. Drug Alcohol Depend. 2011; 114(2-3): 194-200. PMCID: PMC3062675

Publications for 2012

  1. Abraham AG, Palella FJ, Li X, Estrella MM, Kingsley LA, Witt MD, Jacobson LP. The impact of impaired kidney function and HIV infection on the risk of anemia. AIDS Res Hum Retroviruses. 2012; 28(12): 1666-71. PMCID: PMC3505063
  2. Beachler DC, Weber KM, Margolick JB, Strickler HD, Cranston RD, Burk RD, Wiley DJ, Minkoff H, Reddy S, Stammer EE, Gillison ML, D'Souza G. Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults. Cancer Epidemiol Biomarkers Prev. 2012; 21(1): 122-33. PMCID: PMC3280125
  3. Becker JT, Maruca V, Kingsley LA, Sanders JM, Alger JR, Barker PB, Goodkin K, Martin E, Miller EN, Ragin A, Sacktor N, Selnes O. Factors affecting brain structure in men with HIV disease in the post-HAART era. Neuroradiology. 2012; 54(2): 113-21. PMCID: PMC3154580
  4. Brennan CA, Ibarrondo FJ, Sugar CA, Hausner MA, Shih R, Ng HL, Detels R, Margolick JB, Rinaldo CR, Phair J, Jacobson LP, Yang OO, Jamieson BD. Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression. J Virol. 2012; 86(19): 10505-16. PMCID: PMC3457253
  5. Cocohoba JM, Althoff KN, Godfrey R, Palella FJ, Greenblatt RM. Influence of gender on receipt of guideline-based antiretroviral therapy in the era of HAART. AIDS Care. 2012; 24(1): 20-9. PMCID: PMC3222784
  6. Cole SR, Hudgens MG, Tien PC, Anastos K, Kingsley L, Chmiel JS, Jacobson LP. Marginal structural models for case-cohort study designs to estimate the association of antiretroviral therapy initiation with incident AIDS or death. Am J Epidemiol. 2012; 175(5): 381-90. PMCID: PMC3282878
  7. Deng Z, Gao X, Kirk GD, Wolinsky S, Carrington M. Characterization of the HLA-C*07:01:01G allele group in European and African-American cohorts. Hum Immunol. 2012; 73(7): 715-9. PMCID: PMC3377779
  8. Detels R, Jacobson L, Margolick J, Martinez-Maza O, Munoz A, Phair J, Rinaldo C, Wolinsky S. The multicenter AIDS Cohort Study, 1983 to. Public Health. 2012; 126(3): 196-8. PMCID: PMC3324261
  9. Dyer TP, Shoptaw S, Guadamuz TE, Plankey M, Kao U, Ostrow D, Chmiel JS, Herrick A, Stall R. Application of syndemic theory to black men who have sex with men in the Multicenter AIDS Cohort Study. J Urban Health. 2012; 89(4): 697-708. PMCID: PMC3535137
  10. Falade-Nwulia O, Seaberg EC, Rinaldo CR, Badri S, Witt M, Thio CL. Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection. Clin Infect Dis. 2012; 55(4): 507-13. PMCID: PMC3520384
  11. Hart TA, Moskowitz D, Cox C, Li X, Ostrow DG, Stall RD, Gorbach PM, Plankey M. The cumulative effects of medication use, drug use, and smoking on erectile dysfunction among men who have sex with men. J Sex Med. 2012; 9(4): 1106-13. PMCID: PMC3319271
  12. Hechter RC, Budoff M, Hodis HN, Rinaldo CR, Jenkins FJ, Jacobson LP, Kingsley LA, Taiwo B, Post WS, Margolick JB, Detels R. Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: multicenter AIDS cohort study. Atherosclerosis. 2012; 223(2): 433-6. PMCID: PMC3392500
  13. Levine AJ, Service S, Miller EN, Reynolds SM, Singer EJ, Shapshak P, Martin EM, Sacktor N, Becker JT, Jacobson LP, Thompson P, Freimer N. Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults. Am J Med Genet B Neuropsychiatr Genet. 2012; 159B(6): 669-83. PMCID: PMC3418456
  14. Lim SH, Ostrow D, Stall R, Chmiel J, Herrick A, Shoptaw S, Kao U, Carrico A, Plankey M. Changes in stimulant drug use over time in the MACS: evidence for resilience against stimulant drug use among men who have sex with men. AIDS Behav. 2012; 16(1): 151-8. PMCID: PMC3133874
  15. Monroe AK, Dobs AS, Xu X, Palella FJ, Kingsley LA, Post WS, Witt MD, Brown TT. Low free testosterone in HIV-infected men is not associated with subclinical cardiovascular disease. HIV Med. 2012; 13(6): 358-66. PMCID: PMC3505881
  16. Price JC, Seaberg EC, Badri S, Witt MD, D'Acunto K, Thio CL. HIV monoinfection is associated with increased aspartate aminotransferase-to-platelet ratio index, a surrogate marker for hepatic fibrosis. J Infect Dis. 2012; 205(6): 1005-13. PMCID: PMC3282573
  17. Rueda S, Raboud J, Plankey M, Ostrow D, Mustard C, Rourke SB, Jacobson LP, Bekele T, Bayoumi A, Lavis J, Detels R, Silvestre AJ. Labor force participation and health-related quality of life in HIV-positive men who have sex with men: the Multicenter AIDS Cohort Study. AIDS Behav. 2012; 16(8): 2350-60. PMCID: PMC3575137
  18. Schneider MF, Margolick JB, Jacobson LP, Reddy S, Martinez-Maza O, Munoz A. Improved estimation of the distribution of suppressed plasma HIV-1 RNA in men receiving effective antiretroviral therapy. J Acquir Immune Defic Syndr. 2012; 59(4): 389-92. PMCID: PMC3299865
  19. Shoptaw S, Stall R, Bordon J, Kao U, Cox C, Li X, Ostrow DG, Plankey MW. Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study. Int J STD AIDS. 2012; 23(8): 576-80. PMCID: PMC3576843
  20. Thapa DR, Bhatia K, Bream JH, D'Souza G, Rinaldo CR, Wolinsky S, Detels R, Martinez-Maza O. B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas. AIDS. 2012; 26(9): 1177-80. PMCID: PMC3355225
  21. Thomas R, Thio CL, Apps R, Qi Y, Gao X, Marti D, Stein JL, Soderberg KA, Moody MA, Goedert JJ, Kirk GD, Hoots WK, Wolinsky S, Carrington M. A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. J Virol. 2012; 86(12): 6979-85. PMCID: PMC3393572
  22. Westreich D, Cole SR, Young JG, Palella F, Tien PC, Kingsley L, Gange SJ, Hernan MA. The parametric g-formula to estimate the effect of highly active antiretroviral therapy on incident AIDS or death. Stat Med. 2012; 31(18): 2000-9. PMCID: PMC3641816

Publications for 2013

  1. Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. Influence of HLA-C expression level on HIV control. Science. 2013; 340(6128): 87-91. NIHMSID: NIHMS484348
  2. Aziz N, Margolick JB, Detels R, Rinaldo CR, Phair J, Jamieson BD, Butch AW. Value of a quality assessment program in optimizing cryopreservation of peripheral blood mononuclear cells in a multicenter study. Clin Vaccine Immunol. 2013; 20(4): 590-5. PMCID: PMC3623420
  3. Gingo MR, Balasubramani GK, Kingsley L, Rinaldo CR, Jr., Alden CB, Detels R, Greenblatt RM, Hessol NA, Holman S, Huang L, Kleerup EC, Phair J, Sutton SH, Seaberg EC, Margolick JB, Wisniewski SR, Morris A. The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. PLoS One. 2013; 8(3): e58812. PMCID: PMC3595204
  4. Hacioglu Y, Gupta M, Choi TY, George RT, Deible CR, Jacobson LP, Witt MD, Palella FJ, Post WS, Budoff MJ. Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy. Anadolu Kardiyol Derg. 2013; 13(3): 207-14. PMCID: PMC3673004
  5. Herrick AL, Lim SH, Plankey MW, Chmiel JS, Guadamuz TE, Kao U, Shoptaw S, Carrico A, Ostrow D, Stall R. Adversity and syndemic production among men participating in the multicenter AIDS cohort study: a life-course approach. Am J Public Health. 2013; 103(1): 79-85. NIHMSID: NIHMS483256
  6. Herrick AL, Stall R, Chmiel JS, Guadamuz TE, Penniman T, Shoptaw S, Ostrow D, Plankey MW. It gets better: resolution of internalized homophobia over time and associations with positive health outcomes among MSM. AIDS Behav. 2013; 17(4): 1423-30. NIHMSID: NIHMS432621
  7. Hussain SK, Zhu W, Chang SC, Breen EC, Vendrame E, Magpantay L, Widney D, Conn D, Sehl M, Jacobson LP, Bream JH, Wolinsky S, Rinaldo CR, Ambinder RF, Detels R, Zhang ZF, Martinez-Maza O. Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk. Cancer Epidemiol Biomarkers Prev. 2013; 22(2): 295-307. NIHMSID: NIHMS428477
  8. Lane J, McLaren PJ, Dorrell L, Shianna KV, Stemke A, Pelak K, Moore S, Oldenburg J, Alvarez-Roman MT, Angelillo-Scherrer A, Boehlen F, Bolton-Maggs PH, Brand B, Brown D, Chiang E, Cid-Haro AR, Clotet B, Collins P, Colombo S, Dalmau J, Fogarty P, Giangrande P, Gringeri A, Iyer R, Katsarou O, Kempton C, Kuriakose P, Lin J, Makris M, Manco-Johnson M, Tsakiris DA, Martinez-Picado J, Mauser-Bunschoten E, Neff A, Oka S, Oyesiku L, Parra R, Peter-Salonen K, Powell J, Recht M, Shapiro A, Stine K, Talks K, Telenti A, Wilde J, Yee TT, Wolinsky SM, Martinson J, Hussain SK, Bream JH, Jacobson LP, Carrington M, Goedert JJ, Haynes BF, McMichael AJ, Goldstein DB, Fellay J. A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Hum Mol Genet. 2013; 22(9): 1903-10. PMCID: PMC3613165
  9. Nicholaou MJ, Martinson JJ, Abraham AG, Brown TT, Hussain SK, Wolinsky SM, Kingsley LA. HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study. AIDS Res Hum Retroviruses. 2013; 29(6): 871-9. PMCID: PMC3653392
  10. Vo QT, Cox C, Li X, Jacobson LP, McKaig R, Sacktor N, Selnes OA, Martin E, Becker JT, Miller EN. Neuropsychological test performance before and after HIV-1 seroconversion: the Multicenter AIDS Cohort Study. J Neurovirol. 2013; 19(1): 24-31. PMCID: PMC3568242
  11. Wada N, Jacobson LP, Cohen M, French A, Phair J, Munoz A. Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008. Am J Epidemiol. 2013; 177(2): 116-25. PMCID: PMC3590031
  12. Witt MD, Seaberg EC, Darilay A, Young S, Badri S, Rinaldo CR, Jacobson LP, Detels R, Thio CL. Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011. Clin Infect Dis. 2013; 57(1): 77-84. PMCID: PMC3669529

Publications for 2014

  1. Aissani B, Wiener H, Zhang K, Kaslow RA, Ogwaro KM. Shrestha S, Jacobson LP. A candidate gene approach for virally induced cancer with application to HIV-related Kaposi's sarcoma. Int J Cancer 2014;134:397-404. doi: 10.1002/ijc.28351 PMCID: PMC4007164
  2. Aissani B, Boehme AK, Wiener HW, Shrestha S, Jacobson LP, Kaslow RA. SNP screening of central MHC-identified HLA-DMB as a candidate susceptibility gene for HIV-related Kaposi's sarcoma. Genes Immun 2014;15(6):424-429. doi: 10.1038/gene.2014.42. . PMCID: PMC4174341
  3. Althoff KN, Jacobson LP, Cranston RD, Detels R, Phair JP, Li X, Margolick JB for the Multicenter AIDS Cohort Study. Age, comorbidities and AIDS predict the frailty phenotype in men who have sex with men. J Gerontol A Biol Sci Med Sci 2014;69:189-198. doi: 10.1093/gerona/glt148. PMCID: PMC4038242
  4. An P, Goedert JJ, Donfield S, Buchbinder S, Kirk GD, Detels R, Winkler CA. Regulatory variation in HIV-1 dependency factor ZNRD1 associates with host resistance to HIV-1 acquisition. J Infect Dis. 2014;210(10):1539-48. doi: 10.1093/infdis/jiu291. PMCID: PMC4215072
  5. Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, Kirk GD, Fellay J, Buchbinder SP, Goedert JJ, Deeks SG, Pereyra F, Trowsdale J, Lichterfeld M, Telenti A, Walker BD, Allen RL, Carrington M, Yu XG. LILRB2 interaction with HLA class I correlates with control of HIV-1 infection. PLoS Genet. 2014;10(3):e1004196. doi: 10.1371/journal.pgen.1004196. PMCID: PMC3945438
  6. Beachler DC, Abraham AG, Silverberg MJ, Jing Y, Fakhry C, Gill MJ, Dubrow R,Kitahata MM, Klein MB, Burchell AN, Korthuis PT, Moore RD, D'Souza G; On behalf of the North American AIDS Cohort Collaboration on Research and Design(NA-ACCORD) of IeDEA. Incidence and risk factors of HPV-related and HPV-unrelated head and neck squamous cell carcinoma in HIV-infected individuals.Oral Oncol 2014;50(12):1169-1176. doi: 10.1016/j.oraloncology.2014.09.011.PMCID: PMC4253676
  7. Brener M, Ketlogetswe K, Budoff M, Jacobson LP, Li X, Rezaeian P, Razipour A, Palella FJ, Kingsley L, Witt MD, George RT, Post WS. Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis. AIDS 2014;28(11):1635-1644. doi: 10.1097/QAD.0000000000000116. PMCID: PMC4169787
  8. Carrico AW, Shoptaw S, Cox C, Stall R, Li X, Ostrow DG, Vlahov D, Plankey MW.Stimulant use and progression to AIDS or mortality after the initiation of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2014;67(5):508-513. doi:10.1097/QAI.0000000000000364. PMCID: PMC4232455
  9. Cousins MM, Konikoff J, Laeyendecker O, Celum C, Buchbinder SP, Seage GR III,Kirk GD, Moore RD, Mehta SH, Margolick JB, Brown J, Mayer KH, Koblin BA, Wheeler D, Justman JE, Hodder SL, Quinn TC, Brookmeyer R, Eshleman SH. HIV diversity as a biomarker for HIV incidence estimation: Including a high resolution melting diversity assay in a multi-assay algorithm. J Clin Microbiol 2014;52(1):115-121. doi: 10.1128/JCM.02040-13. PMCID: PMC3911463
  10. Cousins MM, Konikoff J, Sabin D, Khaki L, Longosz AF, Laeyendecker O, Celum C,Buchbinder SP, Seage GR 3rd, Kirk GD, Moore RD, Mehta SH, Margolick JB, Brown J, Mayer KH, Kobin BA, Wheeler D, Justman JE, Hodder SL, Quinn TC, Brookmeyer R, Eshleman SH. A comparison of two measures of HIV diversity in multi-assay algorithms for HIV incidence estimation. PLoS One. 2014;9(6):e101043. doi:10.1371/journal.pone.0101043. PMCID: PMC4072769
  11. Erlandson KM, Reynolds SM, Cox C, Palella FJ, Witt MD, Kingsley LA, Brown TT, Plankey M. Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity. PLoS ONE 2014;9(12):e114166. doi: 10.1371/journal.pone.0114166. PMCID: PMC4250188
  12. Friedman MR, Kurtz SP, Buttram ME, Wei C, Silvestre AJ, Stall R. HIV risk among substance-using men who have sex with men and women (MSMW): Findings from South Florida. AIDS Behav. 2014;18(1):111-119. doi: 10.1007/s10461-013-0495-z. PMCID: PMC4034527
  13. Friedman MR, Stall R, Silvestre AJ, Mustanski B, Shoptaw S, Surkan PJ, Rinaldo CR, Plankey MW. Stuck in the middle: longitudinal HIV-related health disparities among men who have sex with men and women. J Acquir Immune Defic Syndr 2014;66(2):213-220. doi: 10.1097/QAI.0000000000000143. PMCID: PMC4030741
  14. Gingo MR, Balasubramani GK, Rice TB, Kingsley L, Kleerup EC, Detels R, Seaberg EC, Greenblatt RM, Holman S, Huang L, Sutton SH, Bertolet M, Morris A. Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts. BMC Pulm Med 2014;14:75. doi: 10.1186/1471-2466-14-75. PMCID: PMC4021087
  15. Hensler HR, Tomaszewski MJ, Rappocciolo G, Rinaldo CR, Jenkins FJ. Human herpesvirus 8 glycoprotein B binds the entry receptor DC-SIGN. Virus Res 2014;190C:97-103. doi: 10.1016/j.virusres.2014.07.003. PMCID: PMC4142096
  16. Ketlogetswe KS, Post WS, Li X, Palella FJ Jr, Jacobson LP, Margolick JB, Kingsley LA, Witt MD, Dobs AS, Budoff MJ, Brown TT. Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men. AIDS 2014;28:901-909. doi: 10.1097/QAD.0000000000000186. PMCID: PMC3967406
  17. Kibirige CN, Menendez FA, Zhang H, Nilles TL, Langan S, Margolick JB. Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells. Med Hypotheses 2014;83(1):69-73. doi: 10.1016/j.mehy.2014.04.005. PMCID:PMC4074401
  18. Levine AJ, Reynolds S, Cox C, Miller EN, Sinsheimer JS, Becker JT, Martin E, Sacktor N, Neuropsychology Working Group of the Multicenter AIDS Cohort Study. The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning. J Neurovirol. 2014;20(3):243-257. doi:10.1007/s13365-014-0241-y. PMCID: PMC4040160
  19. Li H, Margolick JB, Bream JH, Nilles TL, Langan S, Bui HT, Sylwester AW, Picker LJ, Leng SX. Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men. J Infect Dis 2014;210(3):400-404. doi: 10.1093/infdis/jiu093. PMCID: PMC4110456
  20. Longosz AF, Mehta SH, Kirk GD, Margolick JB, Brown J, Quinn TC, Eshleman SH, Laeyendecker O. Incorrect identification of recent HIV infection in adults in the United States using a limiting-antigen avidity assay. AIDS 2014;25(8):1227-1232. PMCID: PMC4102639
  21. Margolick JB, Jacobson LP, Schwartz GJ, Abraham AG, Darilay AT, Kingsley LA, Witt MD, Palella FJ. Factors affecting glomerular filtration rate, as measured by iohexol disappearance rate, in HIV-infected or -uninfected men. PLoS ONE 2014;9:e86311. PMCID: PMC3917840
  22. Mata MM, Iwema JR, Dell S, Neems L, Jamieson BD, Phair J, Cohen MH, Anastos K, Baum LL. Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women. AIDS Res Hum Retroviruses 2014;30(1):50-57. doi: 10.1089/AID.2012.0377. PMCID: PMC3887406
  23. McKenney J, Smith RM, Chiller TM, Detels R, French A, Margolick J, Klausner JD;Centers for Disease Control and Prevention. Prevalence and correlates of cryptococcal antigen positivity among AIDS patients--United States, 1986-2012. MMWR Morb Mortal Wkly Rep. 2014;63(27):585-587. PMCID: PMC Exempt
  24. McKinnon JE, Mailliard RB, Swindells S, Wilkin TJ, Borowski L, Roper JM, Bastow B, Kearney M, Wiegand A, Mellors JW, Rinaldo CR; A5201 Study Team. Baseline natural killer and T cell populations correlation with virologic outcome after regimen simplification to atazanavir/ritonavir alone (ACTG 5201). PLoS One. 2014;9(5):e95524. doi: 10.1371/journal.pone.0095524. PMCID: PMC4011688
  25. Melhem NM, Smith KN, Huang XL, Colleton BA, Jiang W, Mailliard RB, Mullins JI, Rinaldo CR. The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses. Virology 2014;450-451:34-48. PMCID: PMC4110927
  26. Miller PE, Budoff M, Zikusoka M, Li X, Palella F Jr., Kingsley LA, Witt MD, Sharrett AR, Jacobson LP, Post WS. Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter Aids Cohort Study. Am J Cardiol. 2014;114(3):369-375. doi:10.1016/j.amjcard.2014.04.049. PMCID: PMC4143765
  27. Monroe AK, Dobs AS, Palella FJ, Kingsley LA, Witt MD, Brown TT. Morning free and total testosterone in HIV-infected men: implications for the assessment of hypogonadism. AIDS Res Ther 2014;11(1):6. doi: 10.1186/1742-6405-11-6. PMCID: PMC3900935
  28. Ng DK, Jacobson LP, Brown TT, Palella FJ Jr, Martinson JJ, Bolan R, Miller ER 3rd, Schwartz GJ, Abraham AG, Estrella MM. HIV therapy, metabolic and cardiovascular health are associated with glomerular hyperfiltration among men with and without HIV infection. AIDS 2014;28(3):377-386. PMCID: PMC3972628
  29. Nolen BM, Breen EC, Bream JH, Jenkins FJ, Kingsley LA, Rinaldo CR, Lokshin AE. Circulating mediators of inflammation and immune activation in AIDS-related non-hodgkin lymphoma. PLoS One. 2014;9(6):e99144. doi:10.1371/journal.pone.0099144. PMCID: PMC4055650
  30. Patil SP, Brown TT, Jacobson LP, Margolick JB, Laffan A, Johnson-Hill L, Godfrey R, Johnson J, Reynolds S, Schwartz AR, Smith PL. Sleep disordered breathing, fatigue, and sleepiness in HIV-infected and -uninfected men. PloS ONE 2014;9:e99258. PMCID: PMC4084642
  31. Pickering S, Hué S, Kim EY, Reddy S, Wolinsky SM, Neil SJ. Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. PLoS Pathog. 2014;10(1):e1003895. PMCID: PMC3900648
  32. Pines HA, Gorbach PM, Weiss RE, Shoptaw S, Landovitz RJ, Javanbakht M, Ostrow DG, Stall RD, Plankey M. Sexual risk trajectories among MSM in the United States: Implications for pre-exposure prophylaxis delivery. J Acquir Immune Defic Syndr 2014;65:579-586. PMCID: PMC4026016
  33. Post WS, Budoff M, Kingsley L, Palella FJ, Jr., Witt MD, Li X, George RT, Brown TT, Jacobson LP. Associations between HIV infection and subclinical coronary atherosclerosis. Ann Intern Med 2014;160(7):458-467. PMCID
  34. Price JC, Seaberg EC, Latanich R, Budoff MJ, Kingsley LA, Palella FJ Jr, Witt MD, Post WS, Thio CL. Risk factors for fatty liver in the Multicenter AIDS Cohort Study. Am J Gastroenterol 2014;109(5):695-704. PMCID: PMC4133993
  35. Rappocciolo G, Jais M, Piazza P, Reinhart TA, Berendam SJ, Garcia-Exposito L, Gupta P, Rinaldo CR. Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors. mBio. 2014;5(3): e01031-13. PMCID: PMC4010827
  36. Rizvi SM, Salam N, Geng J, Qi Y, Bream JH, Duggal P, Hussain SK, Martinson J,Wolinsky SM, Carrington M, Raghavan M. Distinct assembly profiles of HLA-B molecules. J Immunol 2014;192(11):4967-4976. doi: 10.4049/jimmunol.1301670. PMCID: PMC4117407
  37. Seaberg EC, Witt MD, Jacobson LP, Detels R, Rinaldo CR, Young S, Phair JP, Thio CL. Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men. J Viral Hepat 2014;21(10):696-705. doi: 10.1111/jvh.12198. PMCID: PMC4187219
  38. Shen C, Gupta P, Xu X, Sanyal A, Rinaldo C, Seaberg E, Margolick JB, Martinez-Maza O, Chen Y. Transmission and evolution of hepatitis C virus in HCV seroconverters in HIV infected subjects. Virology. 2014;449:339-349. doi: 10.1016/j.virol.2013.11.001. PMCID: PMC Journal - In Process
  39. Slama L, Li X, Brown T, Jacobson LP, Pialoux G, Macatangay B, Bolan RK, Phair J, Palella FJ Jr. for the Multicenter AIDS Cohort Study. Increases in duration of first highly active antiretroviral therapy over time (1996-2009) and associated factors in the Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 2014;65:57-64. PMCID: PMC3896869
  40. Slama L, Palella F, Abraham A, Li X, Vigouroux C, Pialoux G, Kingsley L, Lake J, Brown T. Inaccuracy of hemoglobin A1c among HIV-infected: Effects of CD4 cell count, antiretroviral therapies, and hematologic parameters. J Antimicrob Chemother. 2014;69(12):3360-3367. doi: 10.1093/jac/dku295. PMCID:PMC4228777
  41. Smith KN, Mailliard RB, Larsen BB, Wong K, Gupta P, Mullins JI, Rinaldo CR. Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1. J Virol 2014;88(17):9976-9990. doi: 10.1128/JVI.01275-14. PMCID: PMC4136313
  42. Thapa DR, Hussain SK, Tran WC, D'Souza G, Bream JH, Achenback CJ, Ayyavoo V, Detels R, Martínez-Maza O. Serum microRNAs in HIV-infected individuals as pre-diagnosis biomarkers for AIDS-NHL. J Acquir Immune Defic Syndr 2014;66(2):229-237. doi: 10.1097/QAI.0000000000000146. PMCID: PMC4096008
  43. Torre P III, Hoffman H, Springer G, Cox C, Young M, Margolick JB, Plankey M. Cochlear function among HIV-seropositive and HIV-seronegative men and women. Ear Hear 2014;35:56-62. PMCID: PMC3872496
  44. Vendrame E, Hussain SK, Breen EC, Magpantay L, Widney DP, Jacobson LP, Variakojis D, Knowlton ER, Bream JH, Ambinder RF, Detels R, Martinez-Maza O. Serum levels of cytokines, and biomarkers for inflammation and immune activation, and HIV-associated non-Hodgkin B cell lymphoma risk. Cancer Epidemiol Biomarkers Prev 2014;23:343-349. PMCID: PMC3948172
  45. Wada N, Jacobson LP, Cohen M, French A, Phair J, Muñoz A. Cause-specific mortality among HIV-infected individuals, by CD4 cell count at HAART initiation, compared to HIV-uninfected individuals. AIDS 2014;28:254-265. PMCID:PMC4164055
  46. Zaccard CR, Watkins SC, Ayyavoo V, Rinaldo CR, Mailliard RB. HIV's ticket to ride: Cytotoxic T-lymphocyte-activated dendritic cells exploited for virus intercellular transfer. AIDS Res Hum Retroviruses. 2014;30(11):1023-4. doi: 10.1089/aid.2014.0218. PMCID: PMC4208601

Publications for 2015

  1. Beachler DC, Sugar EA, Margolick JB, Weber KM, Strickler HD, Wiley DJ, Cranston RD, Burk RD, Minkoff H, Reddy S, Xiao W, Guo Y, Gillison ML, D'Souza G. Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. Am J Epidemiol 2015;181(1):40-53. doi: 10.1093/aje/kwu247. PMCID: PMC Journal - In Process

Funding for MACs is provided by:

FUNDING AGENCYNational Institutes of Health
NIAID U01AI035039 (Wolinsky)
Multicenter AIDS Cohort Study (MACS)

Contact Us


Steven Wolinsky, MD
Division of Infectious Diseases, Feinberg School of Medicine
645 N Michigan Ave, Suite 900
Chicago, IL 60666
Fax 312-695-5088


Shannon Galvin, MD
John Phair, MD
Frank Palella, MD
Sudhir Penugonda, MD
Northwestern University


Northwestern University
645 N Michigan Ave, Suite 900
Chicago, IL 60666
Fax 312-695-5088


Susheel Reddy, MPH